Yes, you're probably right. Since I've been doing Master Backups there really isn't much use to do registry cleaning. I guess I'm just fascinated by the idea of it, and there being so many apps out there that do it. CCleaner's reg cleaner is very mild and that may be the only thing to use. Wise Registry Cleaner takes out the Notepad2 association, so I had to add some items to the don't-remove list in the ppApps I made of the app. Another reg cleaner (at one time) took out all file associations I set up for the "Open With" context -- not true association as 'always open with', but, for example, that Photoshop shows up on the Open With context for jpg's, bmp's, png's, etc. So yeah, they are not always safe those reg cleaners.
So really, reg cleaners would have a greater function for people who don't do regular installs and/or have OS backups -- so basically for computer noobs that probably don't use context menus to begin with

So you're saying that you use multiple VD's at once via UltraISO? I can't recall having done that yet, but I assume that's working OK then?
I've never liked Daemon Tool, or Alcohol 120 (or did that not come with a vd), and apps like that. I did make a ssApp for Virtual CD/DVD Emulator (StarWind Software) that I did like, although it requires a service running. I tweaked it so it won't run the service until you start the app, but still the app requires a few more clicks than UltraISO, tho the VD's are quick and solid. I mean it just feels really smooth to use them for some reason.
Oh, one thing I forgot: UltraISO, since I've been using it on Win7, will not do a proper eject of the VD's a lot of the time. I eject a VD/iso, then later on find it on the U:\ drive again (default for the ssApp I use, I think Kay chose U:\ ). Also, then I eject and reboot the PC some time later, the iso is mounted again on the VD. That has happened a LOT and it's still doing that. It feels like at least half of the time if not all the time, if given time and chance.